Biological Factors Associated with Suicide
Studies have linked suicidal behavior to decreased activity of brain 5- HT pathways. Markers of 5- HT function, such as cerebrospinal fluid (CSF) 5- HIAA and the density of 5- HT transporter sites, are lowered in suicide victims. Abnormalities in brain 5- hydroxytryptamine (5-HT) neurotransmission have been reported in patients with impulsive and aggressive behavior, and low levels of the 5- HT metabolite 5- hydroxy indole acetic acid (5- HIAA) have been found in the cerebrospinal fluid of subjects who have committed acts of unpremeditated violence.
- Harrison PJ, Cowen P, Burns T, Fazel M. Shorter Oxford Textbook of Psychiatry. Oxford: Oxford University Press; 2018., 7th edition, Chapter 21, page no 613).
- Linnoila VM, Virkkunen M. Aggression, suicidality, and serotonin. The Journal of clinical psychiatry. 1992 Oct).
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