Stupor Definition Stupor is defined as a lack of psychomotor activity that may range from not actively relating to the environment to complete immobility. Stupor represents a higher level of consciousness compared to coma, in which there is a complete lack of consciousness as the patients do not respond to painful stimuli. Causes In psychiatry, a stupor may occur in the context of depression, mania or dissociative disorder, respectively known as a depressive stupor, manic stupor or dissociative stupor. It may also be a part of catatonia. Depressive stupor Manic Stupor Dissociative stupor Stupor in catatonia A plethora of medical conditions can cause catatonia and stupor. (Reviewed by: Serra-Mestres et. al, 2018) Subarachnoid hemorrhages, Basal ganglia disorders Non‐convulsive status epilepticus Locked‐in and akinetic mutism states Endocrine and metabolic disorders, e.g. Wilson’s disease, hypoxia Down syndrome, Infections, Dementia Drug toxicity and withdrawal states, even clozapine