Friday, 8 June 2007

Single-photon Emission Tomography SPET

Single-photon Emission Tomography SPET

Principle

uses single-photon (gamma-ray) emitting isotopes

given IV or inhaled

the resolution is lower than PET

Uses

SPET can give information about:

regional cerebral blood flow

ligand binding

Clinical uses include:

Alzheimer’s disease

When the symptomatology (e.g. hallucinations, epilepsy) occurs when the patient is not near a scanner; we can give a suitable ligand at the material time and the patient scanned afterward

Schizophrenia

reduced rCBF in frontal regions—‘hypofrontality’

Affective disorders

as that in schizophrenia, with reversal after antidepressant therapy

Alzheimer’s disease

decreased rCBF in posterior parietal and temporal regions

Xenon inhalation

Shows the failure of activation of frontal lobes in schizophrenics performing the Wisconsin Card Sorting Test


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