Drugs used to Treat Antipsychotic-Induced Weight-Gain (Mnemonic) The following mnemonic is for the drugs used to treat antipsychotic-induced weight gain. The list is not based on priority; however, metformin is the preferred choice, especially when there is comorbid polycystic ovary disease. Orlistat, with calorie restriction, is also an effective choice. FORMAT-B F luoxetine  Orlistat Reboxetine Metformin, methylcellulose, melatonin Topiramate Bupropion 

Typical Versus Atypical Antipsychotics By definition, typical antipsychotics are those which produce extrapyramidal side effects, while atypical antipsychotics do not. However, at the doses used today, most atypical antipsychotics do not produce extrapyramidal side effects. Whether typical and atypical antipsychotics differ in efficacy in a long-held debate. Except for clozapine, there are no significant differences in the efficacy of typical and atypical antipsychotics.  Two large pragmatic studies, CATIE  in the United States, and CutLASS  in the United Kingdom, in 2005 and 2006, respectively, produced similar conclusions. Another meta-analysis, in 2009 showed that risperidone, olanzapine, and amisulpride were more effective compared to typical antipsychotics.  Overall, typical antipsychotics are more likely to produce extrapyramidal side effects, while atypical ones are more likely to produce metabolic side effects, including weight gain, hyperlipemia, and diabetes.  Clozapine is mo

Neuroleptic malignant syndrome  Manifestations MNEMONIC FEVER Fever Encephalopathy Vitals Unstable Enzymes Rigidity of Muscles Treatment Dantrolene D2 agonists (e.g., bromocriptine).