Drugs used to Treat Antipsychotic-Induced Weight-Gain (Mnemonic) The following mnemonic is for the drugs used to treat antipsychotic-induced weight gain. The list is not based on priority; however, metformin is the preferred choice, especially when there is comorbid polycystic ovary disease. Orlistat, with calorie restriction, is also an effective choice. FORMAT-B F luoxetine  Orlistat Reboxetine Metformin, methylcellulose, melatonin Topiramate Bupropion 

Pharmacological Treatment Algorithm for Treatment-Refractory Depression These recommendations are based on the Maudsley Prescribing Guidelines 2018, according to which, depression is treatment refractory when it does not respond to sequential trials of three different antidepressants as recommended in their algorithms.  In the first three steps below, we have enlisted the recommended pharmacological treatment options for an episode of depression. subsequently, we list the options for treatment-refractory depression. Maudsley Prescribing Guidelines focus on the pharmacological treatment options and algorithms, never nevertheless, they acknowledge the important role of non-pharmacological interventions in its treatment and recommend considering one of the appropriate options like cognitive behaviour therapy and/or behavioural activation and other factors identified as being responsible for resistance. Step 1: Recommend an SSRI or mirtazapine. monitor for signs and effects for 3- to 4 w

Treatment of Guidelines for Psychotic Depression First-line        Tricyclic with olanzapine or quetiapine Second choice         SSRI/SNRI Consider Electroconvulsive therapy           

Guidelines for the Pharmacotherapy of Major Depressive Disorder I have summarised the following recommendations from the Maudsley prescribing guidelines in Psychiatry, 13th Ed. Psychotherapies Supportive psychotherapy, CBT, interpersonal therapy, marital/couple therapy, dynamic psychotherapy, behavioral activation Depressive episode Step-1 SRI/ Mirtazapine à A generic SRI; use mirtazapine if sleep needed Step-2 SSRI/non-SRI   à Most evidence is for a switch to vortioxetine Step 3 Mirtazapine, vortioxetine, agomelatine   à if not already trialed