Risk factors for Parkinsonism
- Pesticide exposure
- Head injury
- Drinking well water
- Agricultural occupation
- Use of beta-blockers.
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How do we define NMS?
It is an acute disorder of thermoregulation and neuromotor control that occurs because of exposure to dopaminergic drugs.
What drugs or medications can cause NMS?
Antipsychotics, especially the ones with high anti-dopaminergic potency. But also dopaminergic agonist withdrawal e.g. withdrawal from levodopa.
Criminal behavior, lack of guilt, and irritability are typical features of antisocial personality disorder. Evidence suggests that a low-activity variant of the MAO-A gene predisposes to adult antisocial behavior in men, especially in those who faced early adversity1–4. Catechol-O-methyltransferase enzyme metabolizes dopamine and other monoamines. Its gene, the COMT-gene, occurs in two forms: a high-activity form and a low-activity form. They associate these variants with differential abilities of the prefrontal cortex, especially working memory. People with low-activity form may have a more efficient prefrontal cortex, likely because of the greater dopamine level in the synaptic space5,6. We have associated serotonin transporter gene variants with neuroticism and a predisposition to depression. The variants may also influence individual response to SSRIs8. APOE4 gene is a risk factor for Alzheimer’s disease (compared to APOE2 and APOE3).
ICD-11 Criteria for Gambling Disorder (6C50) A collection of dice Foundation URI : http://id.who.int/icd/entity/1041487064 6C50 Gambling d...