Drugs used to Treat Antipsychotic-Induced Weight-Gain (Mnemonic) The following mnemonic is for the drugs used to treat antipsychotic-induced weight gain. The list is not based on priority; however, metformin is the preferred choice, especially when there is comorbid polycystic ovary disease. Orlistat, with calorie restriction, is also an effective choice. FORMAT-B F luoxetine Orlistat Reboxetine Metformin, methylcellulose, melatonin Topiramate Bupropion