Organic Amnestic Syndrome and Korsakoff Psychosis Dr Waleed Ahmad Vignette A 30-year-old woman is brought to you with memory deficits and rigid behaviour. On examination, she appears lean and weak, dishevelled, is disoriented to time, has a flat affect, registration is 3/3, short-term memory is 0/3 and long-term memory appears intact. She does not have any difficulty naming objects. On physical examination, her weight is 42Kg and her height 152 cm. The lady says, there is nothing wrong with her, while her father says she is speaking too many lies these days. The rest of the clinical evaluation is insignificant except for chronic diarrhoea and recent episodes of vomiting.  What finding will you look for on MRI? Diagnosis The clinical picture, in this case, is consistent with organic amnestic syndrome, specifically Korsakoff Psychosis. The most common cause of organic amnestic syndrome is thiamine deficiency.(1) Magnetic Resonance Imaging Increased signal (ie, hyperintensity) in midline