Wednesday, 13 July 2016

Tourette Syndrome

Tourette Syndrome

Clinical features

>> Diagnostic and Statistical Manual of Mental Disorders, 5th Edition.

  • Multiple vocal and motor tics 
  • Starting before the age of 18 and 
  • Persisting for a duration of at least one year
  • We have excluded other causes of tics.
Learning difficulties 
Social problems 
Emotional disturbances

Maudsley Prescribing Guidelines (13th Edition) 

They recommend alpha-2 agonists such as Clonidine or Guanfacine as the first-line pharmacological treatment for Tics and Tourette Syndrome 

American Family Physicians and Canadian Guidelines

Antipsychotics possess a variety of serious adverse effects (Pringsheim et al., 2012) and even though the evidence base for them is strong, we use them in cases not responding to alpha-2 agonists.


  1. Taylor, D. (2018). The Maudsley Prescribing Guidelines. The Maudsley Prescribing Guidelines. 
  2. Kenney, C., Kuo, S.-H., & Jimenez-Shahed, J. (2008). Tourette’s syndrome. American Family Physician, 77(5), 651–658. Retrieved from
  3. Pringsheim, T., Doja, A., Gorman, D., McKinlay, D., Day, L., Billinghurst, L., … Sandor, P. (2012). Canadian Guidelines for the Evidence-Based Treatment of Tic Disorders: Pharmacotherapy. The Canadian Journal of Psychiatry, 57(3), 133–143. 

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