Cognitive Deficits in Multiple Sclerosis

Impairment of learning, abstraction, memory, and problem-solving occur in patients with multiple sclerosis. These impairments are present in 40% of patients with multiple sclerosis in the community. Sometimes, it is an early manifestation. 

1. Mostly the impairments are seen later in the course.
2. The impairments are mild and progress slowly. 
3. Well-practiced verbal skills are often preserved. 

Cognitive impairment correlates with total lesion load and degree of callosal atrophy on brain imaging. 

LAMP

• Learning
• Abstraction
• Memory
• Problem-solving