Tourette Syndrome Clinical features >> Diagnostic and Statistical Manual of Mental Disorders, 5th Edition. Multiple vocal and motor tics Starting before the age of 18 and Persisting for a duration of at least one year We have excluded other causes of tics. LOSE Learning difficulties Overactivity Social problems Emotional disturbances Maudsley Prescribing Guidelines (13th Edition) They recommend alpha-2 agonists such as Clonidine or Guanfacine as the first-line pharmacological treatment for Tics and Tourette Syndrome American Family Physicians and Canadian Guidelines Antipsychotics possess a variety of serious adverse effects (Pringsheim et al., 2012) and even though the evidence base for them is strong, we use them in cases not responding to alpha-2 agonists. References Taylor, D. (2018). The Maudsley Prescribing Guidelines. The Maudsley Prescribing Guidelines. Kenney, C., Kuo, S.-H., & Jimenez-Shahed, J. (2008). Tourette’s syndro