Sunday, 5 February 2023

Hypofrontality in Schizophrenia

Hypofrontality in Schizophrenia

Hypofrontality, or reduced activity in the brain's frontal lobes, is a well-established feature of schizophrenia. The frontal lobes are responsible for various executive functions, such as planning, decision-making, working memory, and inhibitory control, which are often impaired in individuals with schizophrenia.

Proposed mechanisms

Several studies using neuroimaging techniques, such as positron emission tomography (PET) and functional magnetic resonance imaging (fMRI), have shown reduced activation or metabolism in the frontal lobes of individuals with schizophrenia compared to healthy controls. This hypofrontality has been linked to the negative symptoms and cognitive impairments commonly observed in schizophrenia.
  • reduced blood flow
  • reduced dopaminergic activation
  • reduced metabolism
However, it is important to note that hypofrontality's exact nature and causes in schizophrenia are not yet fully understood and require further research. Additionally, hypofrontality is not specific to schizophrenia and may also be present in other psychiatric conditions.


  1. Lawrie, S. M., & Abukmeil, S. S. (1998). Brain abnormality in schizophrenia: a systematic and quantitative review of volumetric magnetic resonance imaging studies. British Journal of Psychiatry, 172(05), 110-120.
  2. Peltier, S., & Casanova, M. F. (2015). The anatomy of schizophrenia: A review of structural brain imaging studies. Journal of the International Neuropsychological Society, 21(4), 235-255.

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