Saturday, 6 August 2016

Clozapine Induced Neutropenia

Clozapine Induced Neutropenia

It has a risk of 2.7% in patients on clozapine. Fifty percent occur in the first 18 months. The risk is dose-independent, idiosyncratic like neuroleptic malignant syndrome. Risk of agranulocytosis is with clozapine is 0.8%.  

Risk factors: 

Afro-Caribbean ethnicity, early age, low baseline WCC

Mechanism: 

the mechanism of neutropenia and agranulocytosis is unclear

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