Classification of Depression According to the International Classification Diseases, Tenth Revision (ICD-10) Waleed Ahmad The ICD-10 has comprehensively sub-classified into various categories based on the clinical profile of symptoms and the course of symptoms.  Based on the course, it may be a depressive episode, recurrent (major) depressive disorder, persistent depressive disorder or dysthymia, recurrent brief depression, etc. Depression may also be either unipolar or bipolar or it may occur in   A first depressive episode, duration of at least15 days, is classified as a  depressive episode (F32).  If the first depressive episode severe and rapid onset, duration less than 15 days still depressive episode (F32).   A depressive episode can be mild (2 core symptoms, 2 other symptoms from the list) (32.0) moderate (2 core symptoms, 3 or preferably 4 other symptoms) (32.1) Severe (3 core symptoms, 4 other symptoms) without psychotic symptoms (32.2) (no delusion, hallucination or stupor)

Impaired alertness is generally a feature of delirium. In one form of dementia, however, 'fluctuating alertness' is a striking feature. Can you name it? Lewy body dementia

The Safest NSAID for a patient on lithium What is the most suitable non-steroidal anti-inflammatory drug (NSAID) you can prescribe to a patient who is on Lithium therapy? >> Aspirin or Sulindac. 

Can you answer any one or two of these right? 1. In visual perception, the recurrence or prolongation of a visual phenomenon beyond the customary limits of the appearance of the real event in the world is termed ___________ 2. The size of the perception can be either larger '________' or smaller ' ___________' than expected. 3. In some cases, there can be apparent reduction in one hemifield of vision '_____________' 4. These anomalies are common in ______________. 5. Alteration in the customary shape of the perceived object is termed __________ . 6. ‘One woman saw people upside down, on their heads’ (Bleuler, 1950). This is an example of ___________ 7. When metamorphopsia affects faces, it is referred to as __________. 8. , ____________, is the complete absence of colour 9. ______________ refers to the perversion of colour perception 10. . ___________ involves the object appearing far away, 11. __________ is the term used when the object is appearing nearer t

What happens to cellular immune responses in depression? exaggerated reduced

Neuropathology of Alzheimer's Disease Gross Brain Changes The following are the gross changes in the brains of the people with Alzheimer’s disease: Reduced weight of the brain Reduced cortical volume Dilated ventricles Deepening of sulci Magnetic Resonance Imaging On magnetic resonance imaging, the diagnostically most important finding is atrophy , especially of the medial temporal lobe. It affects the entorhinal cortex the earliest but then it spreads to other regions of the temporal lobe and limbic lobe for example hippocampus, amygdala, and parahippocampus. Later, the pathology extends to parietal lobe and eventually global atrophy. It spares frontal lobes until the late stage. The progression of atrophy occurs in a similar pattern as the progression of the neuropathology. Dilated ventricles can show global atrophy, but the most reliable method is a direct measurement of volume. Expansion of the fissures is the indirect, and less reliable way to measure the atrophy. For Alzheime

Neurobiology of Panic Disorder "There is most evidence for changes in Gamma-aminobutyric acid , with lowered cortical Gamma-aminobutyric acid type  levels measured by magnetic resonance spectroscopy, and diminished benzodiazepine -receptor binding in the parietotemporal regions in unmedicated patients with panic disorder (Hasler et al., 2008)." This happens in panic disorder. Gamma-aminobutyric acid is the major  inhibitory  neurotransmitter in the brain. Benzodiazepine also binds to Gamma-aminobutyric acid type A receptors and increases its firing rate, thus resulting in hyperpolarisation of the cell because of increased chloride influx. So, specific regions in the brain are hyperexcitable in patients with panic disorder. Summary of Hasler et al.  Context Studies have implicated the benzodiazepine receptor system in the pathophysiologic mechanism of panic disorder  by indirect evidence from pharmacological challenge studies and by direct evidence from single-photon emission